Syntheses, Crystal Structures and Antibacterial Activities of Two New Methyl 12-Alkylamino-13,14-dinitrodeisopropyl-dehydroabietates

被引：0
作者：
Chen Hao [1 ]
Geng Yi [1 ]
Wang Shi-Fa [1 ]
Gu Wen [1 ]
机构：
[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Prov Key Lab Chem & Utilizat Agroforest B, Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2019年 / 38卷 / 02期
基金：
中国国家自然科学基金;
关键词：
dehydroabietic acid; synthesis; crystal structure; antibacterial activity; DEHYDROABIETIC ACID-DERIVATIVES; NATURAL-PRODUCTS; ANALOGS;
D O I：
10.14102/j.cnki.0254-5861.2011-2088
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The title compounds (5a and 5b) were synthesized from dehydroabietic acid and characterized by MS, IR, NMR and elemental analysis. The crystal structure of compound 5a was determined by single-crystal X-ray diffraction. The compound is of monoclinic system, space group P2(1) with a = 8.0860(16), b = 14.011(3), c = 9.799(2) angstrom,beta = 106.31(3)degrees, Z = 2, V = 1065.5(4) angstrom(3), M-r = 431.48, D-c = 1.345 Mg/m(3), S = 1.002,mu = 0.099 mm(-1), F(000) = 460, the final R = 0.0617 and wR = 0.1532 for 1397 observed reflections (I > 2 sigma(I)). The preliminary antibacterial assay showed that compound 5a exhibited considerable inhibitory activity against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus (MRSA) with MIC values of 2 similar to 8 14/mu L.
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页码：257 / 262
页数：6
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