Prognostic Impact of Fascin-1 (FSCN1) in Epithelial Ovarian Cancer

被引：0

作者：

Hanker, Lars C. ^{[1
]}

Karn, Thomas ^{[1
]}

Holtrich, Uwe ^{[1
]}

Graeser, Monika ^{[2
]}

Becker, Sven ^{[1
]}

Reinhard, Joscha ^{[1
]}

Ruckhaeberle, Eugen ^{[1
]}

Gevensleben, Heidrun ^{[3
]}

Rody, Achim ^{[4
]}

机构：

[1] Goethe Univ, Dept Obstet & Gynecol, Frankfurt, Germany

[2] Univ Med Ctr, Dept Gynecol & Gynecol Oncol, Hamburg, Germany

[3] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

[4] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Lubeck, Germany

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 02期

关键词：

Fascin-1; ovarian cancer; expression; prognosis immunohistochemistry; ACTIN-BUNDLING PROTEIN; MESENCHYMAL TRANSITION; BREAST-CANCER; EXPRESSION; INVASIVENESS; PROGRESSION; CARCINOMA; TUMORS; CELLS; LUNG;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC). Materials and Methods: Expression analysis was performed by immunohistochemistry of paraffin-embedded tumor samples from 89 patients with EOC. Staining intensity and the percentage of positively stained tumor cells were used to calculate an immunoreactive score of 0-12 (IRS). These results were correlated to clinical and pathological characteristics as well as to patient survival. Results: Negative (IRS=0), weak (IRS=0-2) and strong (IRS>2) expression of FSCN1 in EOC was found in 5 (5.6%), 30 (33.7%) and 54 (60.7%) tumor samples, respectively. There was a strong correlation of residual postoperative tumor of >1 cm with higher immunoexpression of FSCNI (p=0.04). Lower FSCN1 expression was associated with significantly poorer overall survival (p=0.02). Conclusion: FSCN1 is frequently expressed in primary EOC. Its prognostic impact and function remains inconclusive and should be further examined in larger trials.

引用

页码：371 / 377

页数：7

共 31 条

[1] Fascin protrusions in cell interactions [J].

Adams, JC .

TRENDS IN CARDIOVASCULAR MEDICINE, 2004, 14 (06) :221-226

[2] Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated Molecules [J].

Al-Alwan, Monther ;

Olabi, Safiah ;

Ghebeh, Hazem ;

Barhoush, Eman ;

Tulbah, Asma ;

Al-Tweigeri, Taher ;

Ajarim, Dahish ;

Adra, Chaker .

PLOS ONE, 2011, 6 (11)

[3]

[Anonymous], 2003, PATHOLOGY GENETICS T

[4] Effect of Screening on Ovarian Cancer Mortality The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial [J].

Buys, Saundra S. ;

Partridge, Edward ;

Black, Amanda ;

Johnson, Christine C. ;

Lamerato, Lois ;

Isaacs, Claudine ;

Reding, Douglas J. ;

Greenlee, Robert T. ;

Yokochi, Lance A. ;

Kessel, Bruce ;

Crawford, E. David ;

Church, Timothy R. ;

Andriole, Gerald L. ;

Weissfeld, Joel L. ;

Fouad, Mona N. ;

Chia, David ;

O'Brien, Barbara ;

Ragard, Lawrence R. ;

Clapp, Jonathan D. ;

Rathmell, Joshua M. ;

Riley, Thomas L. ;

Hartge, Patricia ;

Pinsky, Paul F. ;

Zhu, Claire S. ;

Izmirlian, Grant ;

Kramer, Barnett S. ;

Miller, Anthony B. ;

Xu, Jian-Lun ;

Prorok, Philip C. ;

Gohagan, John K. ;

Berg, Christine D. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (22) :2295-2303

[5] Cell adhesion and signalling by cadherins and Ig-CAMs in cancer [J].

Cavallaro, U ;

Christofori, G .

NATURE REVIEWS CANCER, 2004, 4 (02) :118-132

[6] Ovarian Cancer [J].

Cho, Kathleen R. ;

Shih, Ie-Ming .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2009, 4 :287-313

[7]

Daponte A, 2008, ANTICANCER RES, V28, P1905

[8] Role of Surgical Outcome as Prognostic Factor in Advanced Epithelial Ovarian Cancer: A Combined Exploratory Analysis of 3 Prospectively Randomized Phase 3 Multicenter Trials By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO) [J].

du Bois, Andreas ;

Reuss, Alexander ;

Pujade-Lauraine, Eric ;

Harter, Philipp ;

Ray-Coquard, Isabelle ;

Pfisterer, Jacobus .

CANCER, 2009, 115 (06) :1234-1244

[9] CDNA CLONING AND EXPRESSION OF THE HUMAN HOMOLOG OF THE SEA-URCHIN FASCIN AND DROSOPHILA SINGED GENES WHICH ENCODES AN ACTIN-BUNDLING PROTEIN [J].

DUH, FM ;

LATIF, F ;

WENG, YK ;

GEIL, L ;

MODI, W ;

STACKHOUSE, T ;

MATSUMURA, F ;

DUAN, DR ;

LINEHAN, WM ;

LERMAN, MI ;

GNARRA, JR .

DNA AND CELL BIOLOGY, 1994, 13 (08) :821-827

[10] FASCINS, A FAMILY OF ACTIN BUNDLING PROTEINS [J].

EDWARDS, RA ;

BRYAN, J .

CELL MOTILITY AND THE CYTOSKELETON, 1995, 32 (01) :1-9

← 1 2 3 4 →