Bile Acid Concentration Reference Ranges in a Pregnant Latina Population

被引：6

作者：

Lee, Richard H. ^{[1
]}

Ouzounian, Joseph G. ^{[1
]}

Goodwin, Thomas M. ^{[1
]}

Incerpi, Marc H. ^{[1
]}

Miller, David A. ^{[1
]}

Zhang, Ke ^{[2
]}

Caulfield, Michael P. ^{[2
]}

Reitz, Richard ^{[2
]}

Stanczyk, Frank Z. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA

[2] Quest Diagnost Nichols Inst, San Juan Capistrano, CA USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2013年 / 30卷 / 05期

关键词：

cholestasis; pregnancy; bile; acid; range; INTRAHEPATIC CHOLESTASIS; URSODEOXYCHOLIC ACID; FETAL-DEATH; PREVALENCE; MANAGEMENT;

D O I：

10.1055/s-0032-1326982

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective The total bile acid (TBA) concentration criterion for diagnosing intrahepatic cholestasis of pregnancy varies in the published literature. The purpose of this study was to establish pregnancy-specific reference ranges for the TBA concentration among Latina women. Study Design Self-identified Latina women (n = 211) over 18 years of age with a singleton pregnancy were recruited and had random serum samples drawn during the second and third trimesters. The total and fractionated bile acid concentrations were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and reference ranges were calculated. Laboratory-provided general reference ranges from a general population of adult men and nonpregnant women were used for comparison. Results The TBA reference range for our Latina pregnant population (<8.5 mu mol/L) was markedly lower than the laboratory-provided reference range (4.5 to 19.2 mu mol/L). Conclusion These data suggest that the upper TBA concentration reference range in our Latina pregnant population is 8.5 mu mol/L, based on LC-MS/MS measurements.

引用

页码：389 / 393

页数：5

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