Adiponectin in renal disease - a review of the evidence as a risk factor for cardiovascular and all-cause mortality

被引：3

作者：

Connelly, Philip W. ^{[1
,2
,3
,4
]}

Prasad, G. V. Ramesh ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada

[3] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 1L5, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2012年 / 49卷 / 5-6期

关键词：

Adiponectin; diabetes; renal; kidney; dialysis; coronary heart disease; heart failure; chronic kidney disease; prediabetes; MOLECULAR-WEIGHT ADIPONECTIN; CHRONIC KIDNEY-DISEASE; ENDOTHELIAL-CELL ACTIVATION/INJURY; ADIPOSE-TISSUE CYTOKINES; TYPE-2; DIABETIC-PATIENTS; CORONARY-ARTERY-DISEASE; PLASMA ADIPONECTIN; SERUM ADIPONECTIN; CIRCULATING ADIPONECTIN; INSULIN-RESISTANCE;

D O I：

10.3109/10408363.2012.736470

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Adiponectin, an adipokine, was discovered in 1995. The initial evidence led to the study of adiponectin as a determinant of insulin sensitivity and blood glucose levels. The literature then evolved to reports of the inverse association of adiponectin with incident Type 2 diabetes mellitus and coronary heart disease. Shortly thereafter, reports of a positive association with heart failure and mortality appeared and were replicated. We review here the basic science evidence and clinical studies of the role of renal function and kidney disease as a determinant of adiponectin.

引用

页码：218 / 231

页数：14

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