Age at menopause and menopause-related symptoms in human immunodeficiency virus-infected Thai women

被引:38
作者
Boonyanurak, Pongrak [2 ]
Bunupuradah, Torsak [1 ]
Wilawan, Kittisak [2 ]
Lueanyod, Aksorn [1 ]
Thongpaeng, Parawee [1 ]
Chatvong, Duangjai [1 ]
Sophonphan, Jiratchaya [1 ]
Saeloo, Siriporn [1 ]
Ananworanich, Jintanat [1 ,3 ,4 ]
Chaithongwongwatthana, Surasith [4 ]
机构
[1] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok 10330, Thailand
[2] Phramongkutklao Hosp Royal Thai Army, Bangkok, Thailand
[3] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok 10330, Thailand
[4] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2012年 / 19卷 / 07期
关键词
HIV-infected women; Age at menopause; Menopause-related symptoms; NATURAL MENOPAUSE; HIV-INFECTION; SAMPLE;
D O I
10.1097/gme.0b013e31824cfc0f
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: There are limited data for age at menopause (AM) and menopause-related symptoms in human immunodeficiency virus (HIV)-infected Asian women. We investigated AM and menopause-related symptoms in HIV-infected Thai women. Methods: HIV-infected Thai women 40 years or older who did not receive any hormone therapy in the 8-week period preceding the study were enrolled. Participants completed the Menopause-Specific Quality of Life survey for their symptoms in the past 30 days. Menopause was defined as having the last menstrual period more than 1 year ago. Multivariate Cox proportional hazard regression analysis was used to identify factors associated with menopause. Results: Two hundred sixty-eight HIV-infected women were enrolled; their median age was 44.6 (41.8-48.7) years, and the ratio of their Centers for Disease Control and Prevention clinical classifications (A: B: C) was 53%: 34%: 13%; 95% were using highly active antiretroviral therapy. The median (interquartile range [IQR]) CD4 count was 575 (437-758) cells/mu L, and 93% had HIV-RNA of less than 1.7log(10) copies/mL. Among the 55 women who had reached menopause, the mean (SD) AM was 47.3 (5.1) years. The mean (SD) AM in our study was earlier than the previous report of 49.5 (3.6) years in non-HIV-infected Thai women (difference, -2.2 y; 95% CI, -3.2 to -1.2, P < 0.01). Postmenopausal women had more symptoms, including night sweats (P = 0.03), change in sexual desire (P = 0.01), and avoiding intimacy (P = 0.01), compared with nonpostmenopausal women. No differences in psychosocial or physical domains between groups were found. Factors associated with menopause were Centers for Disease Control and Prevention clinical classification B or C (hazard ratio, 1.7; 95% CI, 1.0-3.03, P = 0.04), and no sexual act in the past month (hazard ratio, 4.9; 95% CI, 1.5-16.0, P = 0.01). No associations of later age of menarche, parity, marital status, educational level, income, body mass index, CD4 count, and HIV-RNA with menopause were found. Conclusions: AM in HIV-infected Thai women was 47.3 years, which is significantly earlier than the findings of a previous AM report on nonYHIV-infected women. Postmenopausal HIV-infected women had more vasomotor and sexual symptoms. More studies are needed to investigate the cause and appropriate interventions for accelerated menopause in HIV-infected women.
引用
收藏
页码:820 / 824
页数:5
相关论文
共 20 条
[1]  
[Anonymous], REP GLOB HIV AIDS EP
[2]   Age at menopause in Latin America [J].
Blumel, Juan E. ;
Chedraui, Peter ;
Calle, Andres ;
Bocanera, Roberto ;
Depiano, Eduardo ;
Figueroa-Casas, Pedro ;
Gonzalez, Carlos ;
Martino, Mabel ;
Royer, Monique ;
Zuniga, Cristina ;
Dulon, Alfredo ;
Espinoza, Maria T. ;
Futchner, Carlos ;
Mostajo, Desire ;
Soto, Edwin ;
Marco, Aurelio A. ;
Aravena, Hernan ;
Busquets, Maritza ;
Campodonico, Italo ;
Germain, Alfredo ;
Alba, Alcira ;
Baron, German ;
Gomez, Gustavo ;
Monterrosa, Alvaro ;
Onatra, Williams ;
Broutin, Gerardo ;
Manzano, Blanca ;
Gabriela, Ayala ;
Hidalgo, Luis ;
Leon, Patricia ;
Orbea, Marcos ;
Sanchez, Hugo ;
Vallejo, Soledad ;
Vallecillo, Gaspar ;
Hernandez-Bueno, Jose A. ;
Motta, Eduardo ;
Andrade, Rafael ;
Tserotas, Konstantinos ;
Gonzalez, Carlos M. ;
Benitez, Zully ;
Calle, Elena ;
Danckers, Luis ;
Del Castillo, Angelica ;
Izaguirre, Humberto ;
Ojeda, Eliana ;
Rojas, Juan ;
Bencosme, Ascanio ;
Lima, Selva .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2006, 13 (04) :706-712
[3]  
Cejtin HE, 2004, 15 INT AIDS C JUL 11
[4]   THE MENOPAUSAL AGE AND CLIMACTERIC COMPLAINTS IN THAI WOMEN IN BANGKOK [J].
CHOMPOOTWEEP, S ;
TANKEYOON, M ;
YAMARAT, K ;
POOMSUWAN, P ;
DUSITSIN, N .
MATURITAS, 1993, 17 (01) :63-71
[5]   Age at menopause of HIV-infected women: A review [J].
Conde, Delio Marques ;
Pinto-Neto, Aarao Mendes ;
Costa-Paiva, Lucia .
GYNECOLOGICAL ENDOCRINOLOGY, 2008, 24 (02) :84-86
[6]   HIV, reproductive aging, and health implications in women: a literature review [J].
Conde, Delio Marques ;
Silva, Emanuela T. ;
Amaral, Waldemar N. ;
Finotti, Marta F. ;
Ferreira, Rui G. ;
Costa-Paiva, Lucia ;
Pinto-Neto, Aarao M. .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2009, 16 (01) :199-213
[7]   Age of menopause and menopausal symptoms in HIV-infected women [J].
Fantry, LE ;
Zhan, M ;
Taylor, GH ;
Sill, AM ;
Flaws, JA .
AIDS PATIENT CARE AND STDS, 2005, 19 (11) :703-711
[8]   Menopause symptoms in women infected with HIV: Prevalence and associated factors [J].
Ferreira, Carlos Eduardo ;
Pinto-Neto, Aarao Mendes ;
Conde, Delio Marques ;
Costa-Paiva, Lucia ;
Morais, Sirlei Siani ;
Magalhaes, Jarbas .
GYNECOLOGICAL ENDOCRINOLOGY, 2007, 23 (04) :198-205
[9]   Factors associated with age at natural menopause in a multiethnic sample of midlife women [J].
Gold, EB ;
Bromberger, J ;
Crawford, S ;
Samuels, S ;
Greendale, GA ;
Harlow, SD ;
Skurnick, J .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 153 (09) :865-874
[10]   A menopause-specific quality of life questionnaire: Development and psychometric properties [J].
Hilditch, JR ;
Lewis, J ;
Peter, A ;
vanMaris, B ;
Ross, A ;
Franssen, E ;
Guyatt, GH ;
Norton, PG ;
Dunn, E .
MATURITAS, 1996, 24 (03) :161-175