Outcomes of older patients in ZUMA-1, a pivotal study of axicabtagene ciloleucel in refractory large B-cell lymphoma

被引：119

作者：

Neelapu, Sattva S. ^{[1
]}

Jacobson, Caron A. ^{[2
]}

Oluwole, Olalekan O. ^{[3
]}

Munoz, Javier ^{[4
]}

Deol, Abhinav ^{[5
]}

Miklos, David B. ^{[6
]}

Bartlett, Nancy L. ^{[7
,8
]}

Braunschweig, Ira ^{[9
]}

Jiang, Yizhou ^{[10
]}

Kim, Jenny J. ^{[10
]}

Zheng, Lianqing ^{[10
]}

Rossi, John M. ^{[10
]}

Locke, Frederick L. ^{[11
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

[2] Dana Farber Canc Inst, Hematol Oncol Treatment Ctr, Boston, MA 02115 USA

[3] Vanderbilt Ingram Canc Ctr, Div Hematol & Oncol, Nashville, TN USA

[4] Banner MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Gilbert, AZ USA

[5] Wayne State Univ, Dept Oncol, Karmanos Canc Ctr, Detroit, MI USA

[6] Stanford Univ, Sch Med, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA

[7] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[8] Siteman Canc Ctr, St Louis, MO USA

[9] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Bronx, NY 10467 USA

[10] Kite, Santa Monica, CA USA

[11] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA

来源：

BLOOD | 2020年 / 135卷 / 23期

关键词：

D O I：

10.1182/blood.2019004162

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2106 / 2109

页数：4

共 14 条

[1]

[Anonymous], 2017, YESCARTA AX CIL PACK

[2]

[Anonymous], 2018, YESCARTA AX CIL SUMM

[3] Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study [J].

Crump, Michael ;

Neelapu, Sattva S. ;

Farooq, Umar ;

Van den Neste, Eric ;

Kuruvilla, John ;

Westin, Jason ;

Link, Brian K. ;

Hay, Annette ;

Cerhan, James R. ;

Zhu, Liting ;

Boussetta, Sami ;

Feng, Lei ;

Maurer, Matthew J. ;

Navale, Lynn ;

Wiezorek, Jeff ;

Go, William Y. ;

Gisselbrecht, Christian .

BLOOD, 2017, 130 (16) :1800-1808

[4] Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial [J].

Locke, Frederick L. ;

Ghobadi, Armin ;

Jacobson, Caron A. ;

Miklos, David B. ;

Lekakis, Lazaros J. ;

Oluwole, Olalekan O. ;

Lin, Yi ;

Braunschweig, Ira ;

Hill, Brian T. ;

Timmerman, John M. ;

Deol, Abhinav ;

Reagan, Patrick M. ;

Stiff, Patrick ;

Flinn, Ian W. ;

Farooq, Umar ;

Goy, Andre ;

McSweeney, Peter A. ;

Munoz, Javier ;

Siddiqi, Tanya ;

Chavez, Julio C. ;

Herrera, Alex F. ;

Bartlett, Nancy L. ;

Wiezorek, Jeffrey S. ;

Navale, Lynn ;

Xue, Allen ;

Jiang, Yizhou ;

Bot, Adrian ;

Rossi, John M. ;

Kim, Jenny J. ;

Go, William Y. ;

Neelapu, Sattva S. .

LANCET ONCOLOGY, 2019, 20 (01) :31-42

[5] Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma [J].

Locke, Frederick L. ;

Neelapu, Sattva S. ;

Bartlett, Nancy L. ;

Siddiqi, Tanya ;

Chavez, Julio C. ;

Hosing, Chitra M. ;

Ghobadi, Armin ;

Budde, Lihua E. ;

Bot, Adrian ;

Rossi, John M. ;

Jiang, Yizhou ;

Xue, Allen X. ;

Elias, Meg ;

Aycock, Jeff ;

Wiezorek, Jeff ;

Go, William Y. .

MOLECULAR THERAPY, 2017, 25 (01) :285-295

[6] Lymphorna incidence patterns by WHO subtype in the United States, 1992-2001 [J].

Morton, LM ;

Wang, SS ;

Devesa, SS ;

Hartge, P ;

Weisenburger, DD ;

Linet, MS .

BLOOD, 2006, 107 (01) :265-276

[7]

NASTOUPIL LJ, 2018, BLOOD S, V132, DOI DOI 10.1182/BLOOD-2018-99-114152

[8]

National Comprehensive Cancer Network, 2019, PLYM M

[9] Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma [J].

Neelapu, S. S. ;

Locke, F. L. ;

Bartlett, N. L. ;

Lekakis, L. J. ;

Miklos, D. B. ;

Jacobson, C. A. ;

Braunschweig, I. ;

Oluwole, O. O. ;

Siddiqi, T. ;

Lin, Y. ;

Timmerman, J. M. ;

Stiff, P. J. ;

Friedberg, J. W. ;

Flinn, I. W. ;

Goy, A. ;

Hill, B. T. ;

Smith, M. R. ;

Deol, A. ;

Farooq, U. ;

McSweeney, P. ;

Munoz, J. ;

Avivi, I. ;

Castro, J. E. ;

Westin, J. R. ;

Chavez, J. C. ;

Ghobadi, A. ;

Komanduri, K. V. ;

Levy, R. ;

Jacobsen, E. D. ;

Witzig, T. E. ;

Reagan, P. ;

Bot, A. ;

Rossi, J. ;

Navale, L. ;

Jiang, Y. ;

Aycock, J. ;

Elias, M. ;

Chang, D. ;

Wiezorek, J. ;

Go, W. Y. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (26) :2531-2544

[10]

Sano D, 2019, Hematol Oncol, V37, P304

← 1 2 →