Lewis acid catalysis in water with a hydrophilic substrate: Scandium-catalyzed hydroxymethylation with aqueous formaldehyde in water

被引：88
|
作者：
Kokubo, Masaya [1 ,2 ]
Ogawa, Chikako [1 ,2 ]
Kobayashi, Shu [1 ,2 ]
机构：
[1] Univ Tokyo, ERATO, JST Hongo, HFRE Div,Grad Sch Pharmaceut Sci,Bunkyo Ku, Tokyo 1130030, Japan
[2] Univ Tokyo, ERATO, JST Hongo, HFRE Div,Dept Chem,Sch Sci,Bunkyo Ku, Tokyo 1130030, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 36期
基金：
日本学术振兴会;
关键词：
asymmetric catalysis; enolates; Lewis acids; sustainable chemistry; synthetic methods;
D O I：
10.1002/anie.200801849
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Synthesis in deep water: For the title reaction, which proceeds with high selectivities, acid-base interactions between the Sc catalyst and HCHO are important. The reaction was used in the synthesis of an odorant to demonstrate its utility (see scheme; ligand DS not shown; PIPd= polymer-incarcerated palladium; BTF=benzotrifluoride). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6909 / 6911
页数：3
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