Hormesis mediates platelet-rich plasma and wound healing

被引：8

作者：

Calabrese, Edward J. ^{[1
,5
]}

Kapoor, Rachna ^{[2
]}

Dhawan, Gaurav ^{[3
]}

Calabrese, Vittorio ^{[4
]}

机构：

[1] Univ Massachusetts, Dept Environm Hlth Sci, Morrill1, N344, Amherst, MA USA

[2] St Francis Hosp & Med Ctr, Hartford, CT USA

[3] Univ Hlth Sci, Sri Guru Ram Das SGRD, Amritsar, India

[4] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Catania, Italy

[5] Univ Massachusetts, Dept Environm Hlth Sci, Morrill1, N344, Amherst, MA 01003 USA

来源：

WOUND REPAIR AND REGENERATION | 2022年

关键词：

cell migration; cell proliferation; complex mixtures; fibroblast; growth factors; hormesis; platelet-rich plasma; transforming growth factor B1; wound healing; HORMETIC DOSE RESPONSES; UMBILICAL-CORD BLOOD; IN-VITRO; FIBROBLAST PROLIFERATION; HISTORICAL FOUNDATIONS; RADIATION HORMESIS; GROWTH; CELLS; DIFFERENTIATION; EXPRESSION;

D O I：

10.1111/wrr.13060

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Platelet-rich plasma (PRP) has become an accepted and general wound healing approach with an extremely wide range of applications. Despite considerable diversity in the composition of platelet-rich plasma products that are applied in specific wound healing usage, it is widely recognised that such diverse platelet-rich plasma complex mixtures routinely display hormetic-like biphasic concentrations that are independent of the tissue treated and endpoints measured. The present paper is the first to place the area of platelet-rich plasma-biomedical research and applications within an hormetic framework. The platelet-rich plasma area is also unique as it represents the application of the hormetic concept to the issue of complex biological mixtures.

引用

页码：56 / 68

页数：13

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