Decreased sensitivity to the cytogenetic effects of bleomycin in individuals occupationally exposed to ionizing radiation

被引：27

作者：

Barquinero, JF

Barrios, L

Caballin, MR

Miro, R

Ribas, M

Subias, A

Egozcue, J

机构：

[1] UNIV AUTONOMA BARCELONA,FAC CIENCIES,UNITAT BIOL CELLULAR,DEPT BIOL CELLULAR & FISIOL,BELLATERRA 08193,SPAIN

[2] UNIV AUTONOMA BARCELONA,INST BIOL FONAMENTAL VICENT VILLAR PALASI,BELLATERRA 08193,SPAIN

[3] UNIV AUTONOMA BARCELONA,FAC MED,UNITAT BIOL,DEPT BIOL CELLULAR & FISIOL,BELLATERRA 08193,SPAIN

[4] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU SANT PAU,SERV ONCOL,BELLATERRA 08193,SPAIN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 354卷 / 01期

关键词：

occupational exposure; ionizing radiation; bleomycin; adaptive response;

D O I：

10.1016/0027-5107(96)00041-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the present work, 12 individuals occupationally exposed to ionizing radiation and 11 unexposed ones were studied to determine the cytogenetic effect of a challenge dose of bleomycin on their phytohemagglutinin stimulated lymphocytes. After bleomycin treatment, the frequencies of chromatid breaks and gaps were significantly lower in the exposed population (p < 0.025 for both types of chromatid alterations). These results could indicate that occupational exposure to ionizing radiation can induce an adaptive response that can be detected by a subsequent treatment with bleomycin.

引用

页码：81 / 86

页数：6

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