A novel fibroblast activation protein-targeted near-infrared fluorescent off-on probe for cancer cell detection, &ITin vitro&IT and &ITin vivo &ITimaging

被引：40

作者：

Xing, Jie ^{[1
,2
,3
,4
]}

Gong, Qiuyu ^{[1
,2
,3
]}

Zou, Ruifen ^{[1
,2
,3
]}

Li, Zihou ^{[1
,2
,3
]}

Xia, Yuanzhi ^{[1
,2
,3
]}

Yu, Zhangsen ^{[1
,2
,3
]}

Ye, Yufan ^{[1
,2
,3
]}

Xiang, Lingchao ^{[1
,2
,3
]}

Wu, Aiguo ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Key Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China

[3] Chinese Acad Sci, Div Funct Mat & Nanodevices, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 10期

基金：

中国博士后科学基金;

关键词：

DIPEPTIDYL-PEPTIDASE-IV; LIVING CELLS; IN-VIVO; TUMOR-GROWTH; THERAPY; TISSUES; DESIGN; ALPHA;

D O I：

10.1039/c7tb03303f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A new hemicyanine-based fibroblast activation protein-targeted near-infrared fluorescent probe is designed and it shows high selectivity and sensitivity to cancer cell detection, and in vitro and in vivo imaging. This probe is successfully applied in fluorescence detection of living cells (with a detection limit of 1500 cells per mL). It is believed that many new functions or distributions of FAP could be discovered by this new probe later.

引用

页码：1449 / 1451

页数：3

共 26 条

[1] Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma [J].