AMYOTROPHIC LATERAL SCLEROSIS AND NEUROSARCOIDOSIS: A CASE REPORT

被引：9

作者：

Chen, I-Hweii Amy ^{[2
,3
]}

Mitsumoto, Hiroshi ^{[2
,3
]}

Vonsattel, Jean P. ^{[1
]}

Hays, Arthur P. ^{[1
]}

机构：

[1] Columbia Univ, Dept Pathol Neuropathol, PH15th Stem,Room 124,630 W 168th St, New York, NY 10032 USA

[2] Columbia Univ, Dept Neurol, New York, NY 10032 USA

[3] Columbia Univ, Eleanor & Lou Gehrig MDA ALS Res Ctr, New York, NY 10032 USA

来源：

MUSCLE & NERVE | 2009年 / 39卷 / 02期

关键词：

amyotrophic lateral sclerosis; sarcoidosis; autopsy ubiquitin; TDP-43; SARCOIDOSIS; TATTOO;

D O I：

10.1002/mus.21159

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without definable biomarkers. The pathomechanism of motor neuron degeneration in ALS has yet to be elucidated. Here we present a case of limb-onset ALS, with autopsy findings of Bunina bodies and skein-like inclusions, as well as sarcoid granulomas predominating among motor neurons. The targeting of the motor neurons by the sarcoid inflammation raises questions regarding the role of cellular immunity in the pathomechanisms for ALS.

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收藏

页码：234 / 238

页数：5

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