The role of Hippo signal pathway in breast cancer metastasis

被引：69

作者：

Wei, Changran ^{[1
]}

Wang, Ying ^{[2
]}

Li, Xiangqi ^{[1
]}

机构：

[1] Affiliated Hosp Taishan Med Univ, Dept Breast Surg, 706 Taishan Rd, Tai An 271000, Shandong, Peoples R China

[2] Affiliated Hosp Taishan Med Univ, Rehabil Med, Tai An, Shandong, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2018年 / 11卷

基金：

中国国家自然科学基金;

关键词：

breast cancer; Hippo signal pathway; metastasis; ORGAN SIZE CONTROL; TUMOR-SUPPRESSOR; CELL-PROLIFERATION; REGULATES HIPPO; BONE METASTASIS; YAP PATHWAY; PROTEIN YAP; STEM-CELLS; TAZ; GROWTH;

D O I：

10.2147/OTT.S157058

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.

引用

页码：2185 / 2193

页数：9

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