Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions

被引：41

作者：

Forte, Maurizio ^{[1
]}

Palmerio, Silvia ^{[1
]}

Bianchi, Franca ^{[1
]}

Volpe, Massimo ^{[1
,2
]}

Rubattu, Speranza ^{[1
,2
]}

机构：

[1] IRCCS Neuromed, Dept Angiocardioneurol, I-86077 Pozzilli, IS, Italy

[2] Sapienza Univ Rome, Osped S Andrea, Sch Med & Psychol, Dept Clin & Mol Med, Rome, Italy

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2019年 / 97卷 / 05期

关键词：

Mitochondrial complex I; Mitochondrial dysfunction; Cardiovascular diseases; Therapeutic interventions; Cardiac hypertrophy; Stroke; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; HEART-FAILURE; CARDIOMYOCYTE APOPTOSIS; CARDIAC-HYPERTROPHY; THERAPEUTIC TARGET; ENZYMATIC-ACTIVITY; CHAIN DYSFUNCTION; REDOX REGULATION; ASSEMBLY FACTOR;

D O I：

10.1007/s00109-019-01771-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associated with cardiac hypertrophy, ischemia/reperfusion injury, as well as diabetic complications and stroke in pre-clinical studies. Moreover, data obtained in humans revealed that genes coding for complex I proteins were associated with different CVDs. In this review, we discuss recent experimental studies that underline the contributory role of mitochondrial complex I deficiency in the etiopathogenesis of several CVDs, with a particular focus on those involving loss of function models of mitochondrial complex I. We also discuss human studies and potential therapeutic strategies able to rescue mitochondrial function in CVDs.

引用

页码：579 / 591

页数：13

共 130 条

[1] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J].

Ahn, Bong-Hyun ;

Kim, Hyun-Seok ;

Song, Shiwei ;

Lee, In Hye ;

Liu, Jie ;

Vassilopoulos, Athanassios ;

Deng, Chu-Xia ;

Finkel, Toren .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14447-14452

[2] Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases [J].

Ajith, Thekkuttuparambil Ananthanarayanan ;

Jayakumar, Thankamani Gopinathan .

WORLD JOURNAL OF CARDIOLOGY, 2014, 6 (10) :1091-1099

[3] Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency. [J].

Anker, Stefan D. ;

Comin Colet, Josep ;

Filippatos, Gerasimos ;

Willenheimer, Ronnie ;

Dickstein, Kenneth ;

Drexler, Helmut ;

Luescher, Thomas F. ;

Bart, Boris ;

Banasiak, Waldemar ;

Niegowska, Joanna ;

Kirwan, Bridget-Anne ;

Mori, Claudio ;

Rothe, Barbara von Eisenhart ;

Pocock, Stuart J. ;

Poole-Wilson, Philip A. ;

Ponikowski, Piotr .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (25) :2436-2448

[4]

[Anonymous], 2016, ADV MED, DOI DOI 10.1155/2016/9152732

[5] Mitochondrial Biology and Neurological Diseases [J].

Arun, Siddharth ;

Liu, Lei ;

Donmez, Gizem .

CURRENT NEUROPHARMACOLOGY, 2016, 14 (02) :143-154

[6] Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy [J].

Ayalon, Nir ;

Flore, Leigh Anne ;

Christensen, Thomas G. ;

Sam, Flora .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 167 (05) :E143-E145

[7] The Cardiac Mitochondrion: Nexus of Stress [J].

Baines, Christopher P. .

ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 :61-80

[8] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) [J].

Bakeeva, L. E. ;

Barskov, I. V. ;

Egorov, M. V. ;

Isaev, N. K. ;

Kapelko, V. I. ;

Kazachenko, A. V. ;

Kirpatovsky, V. I. ;

Kozlovsky, S. V. ;

Lakomkin, V. L. ;

Levina, S. B. ;

Pisarenko, O. I. ;

Plotnikov, E. Y. ;

Saprunova, V. B. ;

Serebryakova, L. I. ;

Skulachev, M. V. ;

Stelmashook, E. V. ;

Studneva, I. M. ;

Tskitishvili, O. V. ;

Vasilyeva, A. K. ;

Victorov, I. V. ;

Zorov, D. B. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1288-1299

[9] Mitochondria as a Therapeutic Target in Heart Failure [J].

Bayeva, Marina ;

Gheorghiade, Mihai ;

Ardehali, Hossein .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (06) :599-610

[10] Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophlic cardiomyopathy and encephalopathy [J].

Bénit, P ;

Beugnot, R ;

Chretien, D ;

Giurgea, I ;

De Lonlay-Debeney, P ;

Issartel, JP ;

Corral-Debrinski, M ;

Kerscher, S ;

Rustin, P ;

Rötig, A ;

Munnich, A .

HUMAN MUTATION, 2003, 21 (06) :582-586

← 1 2 3 4 5 6 7 8 9 10 →