Commensals, probiotics and pathogens in the Caenorhabditis elegans model

被引：78

作者：

Clark, Laura C. ^{[1
]}

Hodgkin, Jonathan ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

CELLULAR MICROBIOLOGY | 2014年 / 16卷 / 01期

基金：

英国医学研究理事会;

关键词：

LIFE-SPAN; C; ELEGANS; DIETARY RESTRICTION; GUT MICROBIOME; E; COLI; BACTERIA; LONGEVITY; GENETICS; RESISTANCE; VIRULENCE;

D O I：

10.1111/cmi.12234

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caenorhabditis elegans is a useful model host for a wide variety of microorganisms that have implications for human health. Recent surveys of mammalian and metazoan microbiota demonstrate the often profound effects of gut commensal bacteria on host lifespan, health and development. Work using C.elegans has revealed the surprising extent to which bacterial metabolism can interact with host pathways with examples from Escherichia coli folate metabolism and Bacillus subtilis nitric oxide synthesis. The C.elegans model has also shed light on the mechanisms by which probiotic bacteria influence lifespan.

引用

收藏

页码：27 / 38

页数：12

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