B-cell Lymphomagenesis in Autoimmune Diseases: the Missing Links

被引：0
作者：
Dias, Catarina [1 ]
Martins, Jorge [1 ]
Dias, Graca [1 ]
Faria, Teresa [1 ]
Brazao, Luz Reis [2 ]
机构：
[1] Cent Hosp Funchal, Dept Internal Med, Autoimmune Dis Unit, P-9054535 Funchal, Madeira Island, Portugal
[2] Cent Hosp Funchal, Dept Internal Med, P-9054535 Funchal, Madeira Island, Portugal
来源：
DISCOVERY MEDICINE | 2012年 / 13卷 / 73期
关键词：
NON-HODGKIN-LYMPHOMA; HEPATITIS-C VIRUS; VITAMIN-D; RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; 25-HYDROXYVITAMIN D; MALT LYMPHOMA; RISK; GENES; SUSCEPTIBILITY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Patients with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome have an increased risk of developing B-cell non-Hodgkin's lymphomas but the mechanisms behind this phenomenon remain unknown. By focusing on recent research reports we explore and discuss some of the proposed mechanisms that contribute to this link. The complexity is enormous and can involve genetic and environmental factors, chronic immune stimulation by antigens, and even the treatment for these autoimmune diseases. These mechanisms can be combined in different ways causing great variability in one's predisposition to lymphomagenesis. Knowing more about these pathways is urgent. The more we know about autoimmune diseases the better we can treat our patients effectively and the more we can prevent lymphomas from developing. [Discovery Medicine 13(73):417-424, June 2012]
引用
收藏
页码：417 / 424
页数：8
相关论文
共 65 条
  • [1] Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions
    Aigelsreiter, Ariane
    Gerlza, Tanja
    Deutsch, Alexander J. A.
    Leitner, Eva
    Beham-Schmid, Christine
    Beham, Alfred
    Popper, Helmut
    Borel, Nicole
    Pospischil, Andreas
    Raderer, Markus
    Kessler, Harald H.
    Neumeister, Peter
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2011, 135 (01) : 70 - 75
  • [2] [Anonymous], ONCOGENE
  • [3] [Anonymous], J CLIN IMMU IN PRESS
  • [4] [Anonymous], ADV HEMATOL
  • [5] [Anonymous], REV MED CHIL
  • [6] Askling J, 2005, ANN RHEUM DIS, V64, P64
  • [7] Cancer - An inflammatory link
    Balkwill, F
    Coussens, LM
    [J]. NATURE, 2004, 431 (7007) : 405 - 406
  • [8] TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    Batten, M
    Fletcher, C
    Ng, LG
    Groom, J
    Wheway, J
    Laâbi, Y
    Xin, XG
    Schneider, P
    Tschopp, J
    Mackay, CR
    Mackay, F
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (02) : 812 - 822
  • [9] Is there a future for TNF promoter polymorphisms?
    Bayley, JP
    Ottenhoff, THM
    Verweij, CL
    [J]. GENES AND IMMUNITY, 2004, 5 (05) : 315 - 329
  • [10] Regulatory T cells and systemic autoimmune diseases: Systemic lupus erythematosus, rheumatoid arthritis, primary Sjogren's syndrome
    Bernard, F.
    Romano, A.
    Granel, B.
    [J]. REVUE DE MEDECINE INTERNE, 2010, 31 (02): : 116 - 127
1234567