Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient

被引：11

作者：

Gueudry, J. ^{[1
]}

Boutolleau, D. ^{[2
,3
]}

Gueudin, M. ^{[4
]}

Burrel, S. ^{[2
,3
]}

Miri, A. ^{[1
]}

Bodaghi, B. ^{[5
]}

Muraine, M. ^{[1
]}

机构：

[1] Charles Nicolle Univ Hosp, Dept Ophthalmol, F-76031 Rouen, France

[2] Univ Paris 06, DETIV ER1, Paris, France

[3] La Pitie Salpetriere Charles Foix Univ Hosp, AP HP, Dept Virol, Paris, France

[4] Charles Nicolle Univ Hosp, Virol Lab, F-76031 Rouen, France

[5] Univ Paris 06, Dept Ophthalmol, DHU Vis & Handicaps, La Pitie Salpetriere Hosp, Paris, France

来源：

JOURNAL OF CLINICAL VIROLOGY | 2013年 / 58卷 / 01期

关键词：

Herpetic keratitis; Cornea; Varicella zoster virus; Acyclovir; Drug resistance; HERPES-ZOSTER; SINE HERPETE;

D O I：

10.1016/j.jcv.2013.04.024

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：318 / 320

页数：3

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