IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

被引：207

作者：

Ben-Sasson, Shlomo Z. ^{[1
,4
]}

Hogg, Alison ^{[2
]}

Hu-Li, Jane ^{[1
]}

Wingfield, Paul ^{[3
]}

Chen, Xi ^{[1
]}

Crank, Michelle ^{[1
]}

Caucheteux, Stephane ^{[1
]}

Ratner-Hurevich, Maya ^{[4
]}

Berzofsky, Jay A. ^{[2
]}

Nir-Paz, Ran ^{[5
]}

Paul, William E. ^{[1
]}

机构：

[1] NIAID, Lab Immunol, Bethesda, MD USA

[2] NCI, Vaccine Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[3] NIAMSD, Prot Express Lab, NIH, Bethesda, MD 20892 USA

[4] Hebrew Univ Jerusalem, Lautenberg Ctr Tumor Immunol, Hadassah Med Ctr, IL-91120 Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Dept Clin Microbiol & Infect Dis, Hadassah Med Ctr, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2013年 / 210卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ADAPTIVE IMMUNE-RESPONSES; TUMOR-NECROSIS-FACTOR; TRANSENDOTHELIAL MIGRATION; ENDOTHELIAL-CELLS; DIFFERENTIAL EXPRESSION; ENVELOPE GLYCOPROTEIN; CYTOKINE PRODUCTION; DENDRITIC CELLS; VACCINIA VIRUS; CD11C(+) CELLS;

D O I：

10.1084/jem.20122006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(-/-) OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B+, have cytotoxic activity, and/ or produce interferon gamma (IFN-gamma). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-gamma when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory.

引用

页码：491 / 502

页数：12

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