Pyrene-Tagged Dendritic Catalysts Noncovalently Grafted onto Magnetic Co/C Nanoparticles: An Efficient and Recyclable System for Drug Synthesis

被引：94

作者：

Keller, Michel ^{[1
,2
]}

Colliere, Vincent ^{[1
,2
]}

Reiser, Oliver ^{[3
]}

Caminade, Anne-Marie ^{[1
,2
]}

Majoral, Jean-Pierre ^{[1
,2
]}

Ouali, Armelle ^{[1
,2
]}

机构：

[1] CNRS, LCC, F-31077 Toulouse 4, France

[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

[3] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 13期

关键词：

catalyst recycling; dendrimers; magnetic nanoparticles; palladium; Suzuki coupling; CROSS-COUPLING REACTIONS; PALLADIUM COMPLEXES; SUPERPARAMAGNETIC NANOPARTICLES; HETEROGENEOUS CATALYST; ORGANIC-SYNTHESIS; SUZUKI REACTION; AQUEOUS-MEDIA; END-GROUPS; WATER; DENDRIMERS;

D O I：

10.1002/anie.201209969

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hold on to your palladium! Phosphines have been grafted on magnetic Co/C nanoparticles through π-π interactions. The resulting Pd complexes showed high activity for Suzuki couplings and the system involving a dendritic ligand was recyclable, allowing the preparation of the drug Felbinac over 12 consecutive runs with minimal Pd leaching. After extraction with CH 2Cl2, Felbinac met the requirements of the pharmaceutical industry (<5 ppm Pd). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3626 / 3629

页数：4

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