Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double-blind, randomized, placebo-controlled study

被引:14
|
作者
Rerknimitr, P. [1 ]
Disphanurat, W. [1 ]
Achariyakul, M. [1 ]
机构
[1] Thammasat Univ, Fac Med, Dept Med, Div Dermatol, Pathum Thani, Thailand
关键词
SKIN; VITILIGO; MELANOCYTES; MIGRATION; FEATURES;
D O I
10.1111/j.1468-3083.2012.04462.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Idiopathic guttate hypomelanosis (IGH) is an idiopathic disorder affecting a large number of people. Effective treatments are not yet available. Objectives To investigate the efficacy of topical 0.1% tacrolimus ointment compared with placebo in the treatment of IGH. Materials and methods Twenty-six patients were included in the study. Lesions on one side of the body were selected to have a treatment with 0.1% tacrolimus ointment, whereas those on the other side served as a control with placebo ointment that had the same physical appearance. Colorimeter was used to assess skin colour at baseline and at 1, 2, 3, 4 and 6months of treatment. Results Mean luminosity scale after adjusted for baseline from the treated side gradually decreased and reached statistical significance compared with the control group after 6months of treatment (P=0.019). Physicians' improvement grading score showed that 11% of the patients demonstrated improvement of their skin lesions on the treated side after 6months' treatment. Conclusion Topical 0.1% tacrolimus ointment appeared to be an effective and safe treatment for IGH. The improvements were best observed by colorimetry, yet, they were not statistically significant upon clinical assessments.
引用
收藏
页码:460 / 464
页数:5
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