Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats

被引：20

作者：

Plaza-Villegas, Francisco ^{[1
]}

Heir, Gary ^{[1
]}

Markman, Stanley ^{[1
]}

Khan, Junad ^{[1
]}

Noma, Noboru ^{[3
]}

Benoliel, Rafael ^{[2
]}

Patel, Jasma ^{[1
]}

Eliav, Eli ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Dent Sch, Ctr Temporomandibular Disorders & Orofacial Pain, Newark, NJ 07103 USA

[2] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Oral Med, Jerusalem, Israel

[3] Nihon Univ, Tokyo, Japan

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2012年 / 114卷 / 04期

关键词：

CHRONIC CONSTRICTION INJURY; INFRAORBITAL NERVE; TRIGEMINAL PAIN; ANALGESICS; HYPERALGESIA; PERSPECTIVE; GABAPENTIN; MANAGEMENT; NEURALGIA; ROTAROD;

D O I：

10.1016/j.oooo.2012.05.002

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat. Study Design. Sixty-four Sprague-Dawley rats underwent infraorbital nerve injury. Seven days after surgery, pain was verified and the rats randomly assigned to topical or systemic treatment with pregabalin or diclofenac, or to no treatment. Pain intensity and motor coordination were assessed at baseline, after surgery, and daily after treatment for 4 consecutive days. Medication plasma levels were assessed at the end of the study. Results. Topical treatment with 10% pregabalin or 5% diclofenac reduced the pain significantly. A significant decrease in motor coordination was found in the systemic pregabalin. The medications' plasma levels were significantly higher in the systemic treatment compared with the topical. Conclusions. Topical treatment with pregabalin or diclofenac can reduce neuropathic orofacial pain induced by nerve injury. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:449-456)

引用

页码：449 / 456

页数：8

共 32 条

[1] Application of a pro-inflammatory agent to the orbital portion of the rat infraorbital nerve induces changes indicative of ongoing trigeminal pain [J].

Benoliel, R ;

Wilensky, A ;

Tal, M ;

Eliav, E .

PAIN, 2002, 99 (03) :567-578

[2] Neuropeptide Y in trigeminal ganglion following chronic constriction injury of the rat infraorbital nerve: is there correlation to somatosensory parameters? [J].

Benoliel, R ;

Eliav, E ;

Iadarola, MJ .

PAIN, 2001, 91 (1-2) :111-121

[3] Clinical characteristics and economic costs of patients with painful neuropathic disorders [J].

Berger, A ;

Dukes, EM ;

Oster, G .

JOURNAL OF PAIN, 2004, 5 (03) :143-149

[4] Prevalence of chronic pain with neuropathic characteristics in the general population [J].

Bouhassira, Didier ;

Lanteri-Minet, Michel ;

Attal, Nadine ;

Laurent, Bernard ;

Touboul, Chantal .

PAIN, 2008, 136 (03) :380-387

[5]

Collins Susanne D, 2005, Expert Opin Emerg Drugs, V10, P95, DOI 10.1517/14728214.10.1.95

[6] Pregabalin for the treatment of fibromyalgia syndrome - Results of a randomized, double-blind, placebo-controlled trial [J].

Crofford, LJ ;

Rowbotham, MC ;

Mease, PJ ;

Russell, IJ ;

Dworkin, RH ;

Corbin, AE ;

Young, JP ;

LaMoreaux, LK ;

Martin, SA ;

Sharma, U .

ARTHRITIS AND RHEUMATISM, 2005, 52 (04) :1264-1273

[7]

ELIAV E, 2008, OROFACIAL PAIN BASIC, P195

[8]

Feinberg SD, 2000, GERIATRICS, V55, P44

[9] Epidemiology and treatment of neuropathic pain: The UK primary care perspective [J].

Hall, Gillian C. ;

Carroll, Dawn ;

Parry, David ;

McQuay, Henry J. .

PAIN, 2006, 122 (1-2) :156-162

[10] Use of topical medication in orofacial neuropathic pain: a retrospective study [J].

Heir, Gary ;

Karolchek, Scott ;

Kalladka, Mythili ;

Vishwanath, Archana ;

Gomes, Julyana ;

Khatri, Raashi ;

Nasri, Cibele ;

Eliav, Eli ;

Ananthan, Sowmya .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2008, 105 (04) :466-469

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