Trichoblastic carcinosarcoma with panfollicular differentiation (panfollicular carcinosarcoma) andCTNNB1(beta-catenin) mutation

被引：5
作者：
Giang, Jenny [1 ]
Biswas, Asok [2 ]
Mooyaart, Antien L. [1 ]
Groenendijk, Floris H. [1 ]
Dikrama, Petra [3 ]
Damman, Jeffrey [1 ]
机构：
[1] Erasmus MC, Dept Pathol, Rotterdam, Netherlands
[2] Univ Edinburgh, Western Gen Hosp, Dept Pathol, Edinburgh, Midlothian, Scotland
[3] Erasmus MC, Dept Dermatol, Rotterdam, Netherlands
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 2021年 / 48卷 / 02期
关键词：
HAIR FOLLICLE MORPHOGENESIS; BETA-CATENIN; CARCINOMA; CTNNB1; GENE;
D O I：
10.1111/cup.13794
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We present a case of trichoblastic carcinosarcoma with panfollicular differentiation. An 80-year-old man presented with a lesion on the left ear, which had been present for several months. Histopathology revealed a well-demarcated neoplasm in the dermis composed of intimately intermingled malignant epithelial and mesenchymal cells. The epithelial component showed multilineage follicular differentiation toward all of the elements of a normal hair follicle. Molecular analysis revealed identical molecular aberrations in both epithelial and mesenchymal components includingCTNNB1andSUFUmutations. To the best of our knowledge, this is the first report of panfollicular carcinosarcoma and of the presence of aCTNNB1mutation in trichoblastic carcinosarcoma.
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收藏
页码：309 / 313
页数：5
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