Elevated serum MDA and depleted non-enzymatic antioxidants, macro-minerals and trace elements are associated with bipolar disorder

被引：38

作者：

Chowdhury, Manjurul Islam ^{[1
]}

Hasan, Maimuna ^{[1
]}

Islam, Mohammad Safiqul ^{[1
]}

Sarwar, Md Shahid ^{[1
]}

Amin, Mohammad Nurul ^{[1
]}

Uddin, S. M. Naim ^{[2
]}

Rahaman, Md Zahedur ^{[1
]}

Banik, Sujan ^{[1
]}

Hussain, Md. Saddam ^{[1
]}

Yokota, Kazushige ^{[3
]}

Hasnat, Abul ^{[4
]}

机构：

[1] Noakhali Sci & Technol Univ, Dept Pharm, Noakhali 3814, Bangladesh

[2] Univ Chittagong, Dept Pharm, Chittagong 4331, Bangladesh

[3] Shimane Univ, Dept Life Sci & Biotechnol, 1060 Nishikawatsu Cho, Matsue, Shimane 6908504, Japan

[4] Univ Dhaka, Fac Pharm, Dept Clin Pharm & Pharmacol, Dhaka 1000, Bangladesh

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2017年 / 39卷

关键词：

Antioxidants; Macro-minerals; Trace elements; Bipolar disorder; Lipid peroxidation; MDA; OXIDATIVE STRESS; LIPID-PEROXIDATION; PREFRONTAL CORTEX; IMMUNE FUNCTION; ZINC; HEALTH; METAANALYSIS; DEPRESSION; POTASSIUM; MELATONIN;

D O I：

10.1016/j.jtemb.2016.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic and neurobiological factors are considered to be the major causes of mood and mental disorders. However, over the past few years, increased levels of serum malondialdehyde and altered levels of various non-enzymatic antioxidants and essential minerals involved in abnormal functional activity have been identified as major contributing factors to the pathogenesis of several neurological disorders. The aim of this study was to determine the levels of the serum lipid peroxidation product malondialdehyde (MDA), antioxidants (vitamin A, E and C), macro-minerals (calcium, potassium and sodium) and trace elements (zinc, iron and selenium) in patients with bipolar disorder and to explore their role in disease progression. This is a prospective case-control study that evaluated 55 patients with bipolar disorder and 55 healthy volunteers matched by age and sex. Serum MDA levels were determined by UV spectrophotometry as a marker of lipid peroxidation. RP-HPLC was employed to investigate the serum vitamin A and E concentrations, whereas UV spectrophotometry was used to quantify levels of vitamin C. Serum macro-minerals and trace elements were analyzed by atomic absorption spectroscopy (AAS). Statistical analysis was performed with independent sample t-tests and Pearson's correlation test. We found significantly higher concentrations of MDA (p < 0.05) and significantly lower concentrations of antioxidants (vitamin A, E and C) (p < 0.05) in the patient group compared with control group. Regarding trace elements and macro-minerals, lower concentrations of zinc, calcium, iron, selenium, sodium and potassium were found in the patient group compared with control subjects (p < 0.05). Our study suggests that high serum MDA concentrations and low serum concentrations of antioxidants, macro-minerals and trace elements are strongly associated with bipolar disorder. (C) 2016 Elsevier GmbH. All rights reserved.

引用

页码：162 / 168

页数：7

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