In vivo function of Rnd2 in the development of neocortical pyramidal neurons

被引：32

作者：

Nakamura, K

Yamashita, Y

Tamamaki, N

Katoh, H

Kaneko, T

Negishi, M

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Mol Neurobiol Lab, Sakyo Ku, Kyoto 6068501, Japan

来源：

NEUROSCIENCE RESEARCH | 2006年 / 54卷 / 02期

关键词：

ganglionic eminence; immunohistochemistry; in situ hybridization; in vivo electroporation; neocortical development; radial migration; subventricular zone; ventricular zone;

D O I：

10.1016/j.neures.2005.10.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the in vivo role of Rnd2, a Rho family small GTPase, in brain development. Rnd2 was expressed by radially migrating cells, which primarily develop to pyramidal neurons, during their stay in the subventricular zone of embryonic cerebral cortex and hippocampus. Exogenous expression of wild-type and a constitutively active Rnd2, but not a negative mutant of Rnd2, in radially migrating cells by in utero electroporation disturbed their morphology and migration to upper layers. These results indicate that Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：149 / 153

页数：5

共 23 条

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