Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges

被引：6

作者：

Ozaki, Yuichi ^{[1
]}

Imanishi, Toshio ^{[1
]}

Akasaka, Takashi ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Cardiovasc Med, Wakayama 6418510, Japan

来源：

CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 23期

关键词：

Biomarker; diagnosis; peripheral artery disease; prognosis; therapy; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERCELLULAR-ADHESION MOLECULE-1; PLASMA-FIBRINOGEN CONCENTRATION; OPTICAL COHERENCE TOMOGRAPHY; NUTRITION EXAMINATION SURVEY; ANKLE-ARM INDEX; RISK-FACTORS; CARDIOVASCULAR-DISEASE;

D O I：

10.2174/0929867322666150630141200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peripheral artery disease (PAD) is an inflammatory disease caused by atherosclerosis. It has been demonstrated that PAD is related to chronic inflammation. While conventional risk factors lead to the pathogenesis and progression of PAD, the role of novel inflammatory biomarkers in relation to PAD is being increasingly recognized. The novel biomarkers for PAD may allow for earlier screening and detection, suppression of disease progression, and development of new therapeutic approaches. In this review, inflammatory biomarkers that should be contributory to diagnosis, prognosis, and avenues for therapeutic challenges in PAD are summarized.

引用

页码：2744 / 2753

页数：10

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