Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide

被引：25
|
作者：
Fedeli, Donatella
Montani, Maura [2 ]
Carloni, Manuel
Nasuti, Cinzia
Amici, Augusto [2 ]
Gabbianelli, Rosita [1 ]
机构：
[1] Univ Camerino, UNICAM, Sch Pharm, Via Gentile 3 Varano, I-62032 Camerino, MC, Italy
[2] Univ Camerino, Sch Biosci & Biotechnol, I-62032 Camerino, MC, Italy
来源：
BIOMARKERS | 2012年 / 17卷 / 07期
关键词：
Nurr1; NF-kappa B; Nrf2; leukocyte; cytokines; permethrin; rat; NF-KAPPA-B; OXIDATIVE STRESS; TRANSCRIPTION; PYRETHROIDS; ACTIVATION; SYSTEM; SWITCH; DAMAGE; GENES; CELLS;
D O I：
10.3109/1354750X.2012.706641
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effect of a low dose of the insecticide permethrin administered during early-life was evaluated on leukocytes inflammation mediators on 300- and 500-day-old rats. Nurr1, NF-kappa B-p65, Nrf2, lipid peroxidation and GSH levels increased with age but compared to the control group, treatment with permethrin induced a significant increase only of Nurr1 and lipid peroxidation in oldest rats. TNF-alpha and Rantes increased, while IL-1 beta, IL-2, IL-13 decreased in oldest treated rats. The results propose Nurr1, TNF-alpha, Rantes, GSH and plasma lipid peroxidation as peripheral biomarkers for monitoring the impact of early-life environmental exposure to xenobiotics in old age.
引用
收藏
页码：604 / 609
页数：6
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