Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile

被引：43

作者：

da Silva, Emerson Rodrigo ^{[1
,2
]}

Alves, Wendel Andrade ^{[1
]}

Castelletto, Valeria ^{[2
]}

Reza, Mehedi ^{[3
]}

Ruokolainen, Janne ^{[3
]}

Hussain, Rohanah ^{[4
]}

Hamley, Ian William ^{[2
]}

机构：

[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, Brazil

[2] Univ Reading, Dept Chem, Whiteknights Reading RG6 6AD, Berks, England

[3] Aalto Univ, Sch Sci, Dept Appl Phys, FIN-00076 Aalto, Finland

[4] Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 58期

基金：

巴西圣保罗研究基金会; 英国工程与自然科学研究理事会;

关键词：

LEUCINE ZIPPER; MOLECULES; HYDRATION; RANGE;

D O I：

10.1039/c5cc03640b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-assembly of peptide nanotubes formed by an L-glutamic acid-based bolaamphiphile is shown to proceed via a remarkable mechanism where the peptide conformation changes from beta-sheet to unordered. The kinetics of this process are elucidated via X-ray scattering and UV circular dichroism methods. The reverse transition from "unordered'' to beta-sheet structures is triggered by UV radiation.

引用

页码：11634 / 11637

页数：4

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