An efficient direct-aldol addition of methyl ketones with aldehydes promoted by MgI2 etherate

被引：2

作者：

Liu, Yingshuai ^{[1
]}

Shen, Hangzhou ^{[1
]}

Zhang, Xingxian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Zhejiang, Peoples R China

来源：

MAIN GROUP METAL CHEMISTRY | 2012年 / 35卷 / 3-4期

关键词：

aldehydes; direct-aldol; ketones; MgI2; etherate; CONDENSATION; MILD;

D O I：

10.1515/mgmc-2012-0029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Direct aldol addition of ketones with aromatic aldehydes and vinyl aldehyde was carried out efficiently in the presence of MgI2 etherate and Et3N using untreated reagent grade CH2Cl2 under atmospheric conditions in a mild, efficient and highly chemoselective manner. Iodide counterion and non-coordinating reaction media (i.e., CH2Cl2) are among the critical factors for the unique reactivity of this reaction system.

引用

页码：111 / 115

页数：5

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