The intestinal epithelium tuft cells: specification and function

被引：187
作者：
Gerbe, Francois [1 ,2 ,3 ,4 ,5 ]
Legraverend, Catherine [1 ,2 ,3 ,4 ,5 ]
Jay, Philippe [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Inst Funct Genom, F-34094 Montpellier 5, France
[2] CNRS, UMR5203, F-34094 Montpellier, France
[3] CNRS, INSERM, U661, F-34094 Montpellier, France
[4] Univ Montpellier I, F-34094 Montpellier, France
[5] Univ Montpellier 2, F-34094 Montpellier, France
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 17期
关键词：
Tuft cells; Brush cells; Intestinal epithelium; Atoh1; Cell differentiation; Dclk1; MOUSE SMALL-INTESTINE; ALVEOLAR BRUSH CELL; RAT SMALL-INTESTINE; TASTE RECEPTORS; STEM-CELLS; FIBRILLOVESICULAR CELLS; ENTEROENDOCRINE CELLS; TRANSCRIPTION FACTOR; ELECTRON-MICROSCOPY; ENTERO-ENDOCRINE;
D O I：
10.1007/s00018-012-0984-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.
引用
收藏
页码：2907 / 2917
页数：11
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