Metabolism of isometheptene in human urine and analysis by gas chromatography-mass spectrometry in doping control

被引：8

作者：

Lyris, E

Tsiakatouras, G

Angelis, Y

Koupparis, M

Spyridaki, MH

Georgakopoulos, C

机构：

[1] Olymp Athlet Ctr Athens, Doping Control Lab Athens, Maroussi 15123, Greece

[2] Univ Athens, Dept Chem, Analyt Chem Lab, GR-15771 Athens, Greece

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2005年 / 827卷 / 02期

关键词：

doping control; isometheptene; gas chromatography-mass spectrometry; heptaminol;

D O I：

10.1016/j.jchromb.2005.09.037

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A study of the metabolism of isometheptene, an antispasmodic drug, in man and comparison with heptaminol metabolism, is presented in this paper. Isometheptene and two metabolites were detected in human urine after oral administration of a tablet containing isometheptene mucate. The urine level of the parent drug, which is excreted during the first 24 h, was determined using gas chromatography-mass spectrometry, after alkaline extraction with organic solvent. A minor metabolite of isometheptene was converted to heptaminol in vitro under the acidic hydrolysis conditions used for the screening procedure of stimulants and narcotics in doping control analysis. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：199 / 204

页数：6