The fibroblast growth factor family: involvement in the regulation of folliculogenesis

被引：52
作者：
Chaves, Roberta Nogueira [1 ]
Tavares de Matos, Maria Helena [2 ]
Buratini, Jose, Jr. [3 ]
de Figueiredo, Jose Ricardo [1 ]
机构：
[1] Univ Estadual Ceara, Fac Vet Med, Lab Manipulat Oocytes & Preantral Follicles, BR-60740903 Fortaleza, CE, Brazil
[2] Fed Univ Sao Francisco Valley, BR-48902300 Petrolina, PE, Brazil
[3] Univ Estadual Paulista, Dept Physiol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
来源：
REPRODUCTION FERTILITY AND DEVELOPMENT | 2012年 / 24卷 / 07期
关键词：
culture medium; development; follicles; ovary; survival; FOLLICLE-STIMULATING-HORMONE; GRANULOSA-CELL VIABILITY; FACTOR EXPRESSION; MESSENGER-RNA; FACTOR FGF; IN-VITRO; RECEPTOR SPECIFICITY; PRIMORDIAL FOLLICLES; PREANTRAL FOLLICLES; ANGIOGENIC FACTORS;
D O I：
10.1071/RD11318
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several growth factors have been identified as local regulators of follicle development and ovulation. Fibroblast growth factor (FGF) family members are potent mitogens and are involved in cell differentiation, cell migration and angiogenesis in many tissues and organs. In addition to FGF-2, which is the most-studied FGF, other important members are FGF-1, -5, -7, -8, -9 and -10. A number of studies have indicated that FGFs play important roles in regulating the initiation of primordial follicle growth, oocyte and follicle survival, granulosa and theca cell proliferation and differentiation, corpus luteum formation, steroidogenesis and angiogenesis. The purpose of this review is to highlight the importance of the FGFs on mammalian female reproduction, providing a better understanding of the roles of this family in ovarian physiology and female fertility.
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收藏
页码：905 / 915
页数：11
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