Alkaloids from Toddalia asiatica and their cytotoxic, antimicrobial and antifungal activities

被引：89

作者：

Hu, Jiang ^{[1
,2
]}

Shi, Xiaodong ^{[1
]}

Chen, Jiangang ^{[1
]}

Mao, Xia ^{[1
]}

Zhu, Lei ^{[1
]}

Yu, Long ^{[1
]}

Shi, Junyou ^{[2
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Environm Sci, Qujing 655011, Peoples R China

[2] Qujing Normal Univ, Inst Characterist Med Resource Ethn Minor, Qujing 655011, Peoples R China

来源：

FOOD CHEMISTRY | 2014年 / 148卷

关键词：

Toddalia asiatica; Rutaceae; Alkaloids; Cytotoxic; Antimicrobial; Antifungal; ZANTHOXYLUM-NITIDUM; SANGUINARINE; ROOTS; BINDING;

D O I：

10.1016/j.foodchem.2012.12.058

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the ethanol extract from the roots of Toddalia asiatica resulted in the isolation of eight new alkaloids, 8-methoxynorchelerythrine (1), 11-demethylrhoifoline B (2), 8-methoxynitidine (3), 8-acetylnorchelerythrine (4), 8,9,10,12-tetramethoxynorchelerythrine (5), isointegriamide (6), 1-demethyl dicentrinone (7), and 11-hydroxy-10-methoxy-(2,3)-methylenedioxytetrahydroprotoberberine (8), together with 10 known alkaloids. Their structures were determined on the basis of spectroscopic analyses, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The isolated components were evaluated in vitro for cytotoxic activities against eight tumor cell lines, antimicrobial activities against two Gram-positive bacteria and five Gram-negative bacteria, and antifungal activities against five pathogens. Benzo[c]phenanthridine and secobenzo[c]phenantridine alkaloids exhibited significant cytotoxic, antimicrobial and antifungal properties. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：437 / 444

页数：8

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