Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides

被引：31

作者：

Almasirad, Ali

Hosseini, Rohollah

Jalalizadeh, Hassan

Rahimi-Moghaddam, Zohreh

Abaeian, Nazila

Janafrooz, Maryam

Abbaspour, Mohammad

Ziaee, Vahid

Dalvandi, Afshin

Shafiee, Abbas ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem, Tehran 14174, Iran

[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14174, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tehran 14174, Iran

[4] Islamic Azad Univ, Fac Pharm, Dept Med Chem, Tehran 19419, Iran

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 06期

关键词：

2-phenoxybenzoic acid hydrazide; N-phenylanthranilic acid hydrazide; analgesic activity;

D O I：

10.1248/bpb.29.1180

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.

引用

页码：1180 / 1185

页数：6

共 29 条

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