Stem Cells for the Treatment of Skeletal Muscle Injury

被引：69

作者：

Quintero, Andres J. ^{[2
,3
,4
]}

Wright, Vonda J. ^{[5
]}

Fu, Freddie H. ^{[2
]}

Huard, Johnny ^{[1
,2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh, Stem Cell Res Ctr, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA

[3] Dept Microbiol & Mol Genet, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15203 USA

来源：

CLINICS IN SPORTS MEDICINE | 2009年 / 28卷 / 01期

关键词：

Sports injury; Stem cells; Tissue engineering; Fibrosis; Regeneration; Skeletal muscle; EXERTIONAL COMPARTMENT SYNDROME; PROGENITOR CELLS; ELECTRICAL-STIMULATION; ANTIFIBROSIS AGENT; GENE-EXPRESSION; SPORTS INJURIES; SATELLITE CELLS; HEALING-PROCESS; MYOGENIC CELLS; REGENERATION;

D O I：

10.1016/j.csm.2008.08.009

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Skeletal muscle injuries are extremely common, accounting for up to 35%-55% of all sports injuries and quite possibly affecting all musculoskeletal traumas. These injuries result in the formation of fibrosis, which may lead to the development of painful contractures, increases patients' risk for repeat injuries, and limits their ability to return to a baseline or pre-injury level of function. The development of successful therapies for these injuries must consider the pathophysiology of these musculoskeletal conditions. We discuss the direct use of muscle-derived stem cells and some key cell population dynamics as well as the use of clinically applicable modalities that may enhance the local supply of stem cells to the zone of injury by promoting angiogenesis.

引用

页码：1 / +

页数：12

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