SNP detection and comparative linkage mapping of 66 bone-related genes in the pig

被引：12

作者：

Onteru, S. K. ^{[1
,2
]}

Fan, B. ^{[1
,2
,3
]}

Rothschild, M. F. ^{[1
,2
]}

机构：

[1] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA

[2] Iowa State Univ, Ctr Integrated Anim Genom, Ames, IA 50011 USA

[3] Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Coll Anim Sci & Technol, Wuhan, Peoples R China

来源：

CYTOGENETIC AND GENOME RESEARCH | 2008年 / 122卷 / 02期

关键词：

D O I：

10.1159/000163089

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteoporosis is a multigenic complex disorder. Though the mouse and rat are used as experimental models for human osteoporosis, the pig bone remodeling cycle is histologically more similar to human than the rat or mouse. Moreover, livestock genomics have many advantages over model organisms and human studies for complex trait dissection. Hence, in the present work 66 bone-related genes were newly genetically mapped on pig chromosomes. Comparative chromosomal patterns of bone-related genes in the pig, human, mouse and rat provide clues that the chromosomal organization of bone-related genes in pigs is more similar to human than that of the mouse and rat. Therefore, the pig can be considered as one of the better models for studying the molecular genetics of bone-related disorders. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：122 / 131

页数：10

共 88 条

[1] A possible new role for vitamin D-Binding protein in osteoclast control:: Inhibition of extracellular Ca2+ sensing at low physiological concentrations [J].

Adebanjo, OA ;

Moonga, BS ;

Haddad, JG ;

Huang, CLH ;

Zaidi, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 249 (03) :668-671

[2] Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency [J].

Ahn, Jong Deok ;

Dubern, Beatrice ;

Lubrano-Berthelier, Cecile ;

Clement, Karine ;

Karsenty, Gerard .

ENDOCRINOLOGY, 2006, 147 (07) :3196-3202

[3] Wnt/β-catenin signaling [J].

Akiyama, T .

CYTOKINE & GROWTH FACTOR REVIEWS, 2000, 11 (04) :273-282

[4] Mapping quantitative trait loci for principal components of bone measurements and osteochondrosis scores in a wild boar x Large White intercross [J].

Andersson-Eklund, L ;

Uhlhorn, H ;

Lundeheim, N ;

Dalin, G ;

Andersson, L .

GENETICAL RESEARCH, 2000, 75 (02) :223-230

[5] Urinary γ-glutamyltransferase (GGT) as a potential marker of bone resorption [J].

Asaba, Yutaro ;

Hiramatsu, Kiyoshi ;

Matsui, Yasumoto ;

Harada, Atsushi ;

Nimura, Yuji ;

Katagiri, Nobuyoshi ;

Kobayashi, Toshihiro ;

Takewaka, Tsuyoshi ;

Ito, Masako ;

Niida, Shumpei ;

Ikeda, Kyoji .

BONE, 2006, 39 (06) :1276-1282

[6] Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone [J].

Asou, Y ;

Rittling, SR ;

Yoshitake, H ;

Tsuji, K ;

Shinomiya, K ;

Nifuji, A ;

Denhardt, DT ;

Noda, M .

ENDOCRINOLOGY, 2001, 142 (03) :1325-1332

[7] Genetic determinants of bone mass [J].

Baldock, PA ;

Eisman, JA .

CURRENT OPINION IN RHEUMATOLOGY, 2004, 16 (04) :450-456

[8] Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells [J].

Banyard, J ;

Bao, L ;

Zetter, BR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :20989-20994

[9] Regulation of osteoblastogenesis and bone mass by Wnt10b [J].

Bennett, CN ;

Longo, KA ;

Wright, WS ;

Suva, LJ ;

Lane, TF ;

Hankenson, KD ;

MacDougald, OA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (09) :3324-3329

[10]

BILEZIKIAN JP, 2002, PRINCIPLES BONE BIOL, V1, P39

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