Age-related changes of aquaporin expression patterns in the postnatal rat retina

被引：16

作者：

Ortak, Huseyin ^{[1
]}

Cayli, Sevil ^{[2
]}

Ocakli, Seda ^{[2
]}

Sogut, Erkan ^{[3
]}

Ekici, Fatih ^{[4
]}

Tas, Ufuk ^{[5
]}

Demir, Selim ^{[1
]}

机构：

[1] Gaziosmanpasa Univ, Fac Med, Dept Ophthalmol, Tokat, Turkey

[2] Gaziosmanpasa Univ, Fac Med, Dept Histol & Embryol, Tokat, Turkey

[3] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey

[4] Yildirim Beyazit Univ, Fac Med, Dept Physiol, Ankara, Turkey

[5] Gaziosmanpasa Univ, Fac Med, Dept Anat, Tokat, Turkey

来源：

ACTA HISTOCHEMICA | 2013年 / 115卷 / 04期

关键词：

Aquaporins; Retinal degeneration; Aging; Rat; MULLER CELLS; MOUSE RETINA; PIGMENT EPITHELIUM; GLIAL AQUAPORINS; WATER CHANNELS; AMACRINE CELLS; OPTIC-NERVE; IMMUNOREACTIVITY; LOCALIZATION; ALTERS;

D O I：

10.1016/j.acthis.2012.09.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies revealed that the rat retina contains numerous membrane-located water channels, the aquaporins (AQPs). Protein expression patterns of AQP1-4, 6 and 9 were examined by immunohistochemistry. In the present study, we investigated the immunolocalization of AQP1-4, 6 and 9 during postnatal development in the rat retina and examined the effect of age on the tissue distribution of these channels. AQP1, 3, 4, 6 and 9 showed gradually increased expression in rat retinas from postnatal week 1 to week 12, and decreased in the 40-week-old rat retinas. AQP2 expression was barely seen in the first week in rat retinas and displayed a significant increase from week 1 to week 4, however no significant alteration of AQP2 was observed after 4 weeks of development. AQP1 and 4 immunoreactivities were present in the inner limiting membrane (ILM), the ganglion cell layer (GCL), inner nuclear layer (INL) and retinal pigment epithelium (RPE) in the 4-, 12- and 40-week-old rat retinas. The RPE, OLM and ILM showed a remarkable expression of AQP1-4, 6 and 9 in the 4, 12 and 40-week-old rat retinas. The reduced expression of AQPs in aged rat retinas may indicate the involvement of AQPs in the pathogenesis of age-related retinal diseases. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：382 / 388

页数：7

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