Chemoimmunotherapy as long-term maintenance therapy for cancer

被引：12

作者：

Egilmez, Nejat K. ^{[1
]}

Harden, Jamie L. ^{[1
]}

Rowswell-Turner, Rachael B. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Microbiol & Immunol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

chemoimmunotherapy; Interleukin-12; spontaneous tumors; immune regulation; chronic treatment; ANTITUMOR IMMUNITY; IFN-GAMMA; VACCINES; TUMORS; CURE;

D O I：

10.4161/onci.19369

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Homeostatic immune regulatory mechanisms can mediate premature termination of therapy-induced antitumor T-effector cell responses. Administration of cyclophosphamide (CY) prior to intratumoral IL-12 and GM-CSF delivery blocked post-treatment T-suppressor cell rebound via elimination of the pre-existing T-suppressor cell pool, allowed repeated activation of antitumor cytotoxic T-cells and resulted in the cure of advanced spontaneous tumors.

引用

页码：563 / 565

页数：3

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