Shiga toxins

被引：154

作者：

Bergan, Jonas ^{[1
,2
,3
]}

Lingelem, Anne Berit Dyve ^{[1
,2
,3
]}

Simm, Roger ^{[1
,2
]}

Skotland, Tore ^{[1
,2
]}

Sandvig, Kirsten ^{[1
,2
,3
]}

机构：

[1] Oslo Univ Hosp, Dept Biochem, Inst Canc Res, Norwegian Radium Hosp, N-0379 Oslo, Norway

[2] Univ Oslo, Ctr Canc Biomed, Fac Med, N-0316 Oslo, Norway

[3] Univ Oslo, Dept Mol Biosci, N-0316 Oslo, Norway

来源：

TOXICON | 2012年 / 60卷 / 06期

关键词：

Shiga toxin; Verotoxin; Ribosome-inactivating proteins; Globotriaosylceramide; HEMOLYTIC-UREMIC SYNDROME; ESCHERICHIA-COLI O157-H7; TO-GOLGI TRANSPORT; NUCLEOTIDE-SEQUENCE ANALYSIS; ACTIVATED PROTEIN-KINASE; PERIPHERAL BENZODIAZEPINE-RECEPTOR; N-GLYCOSIDASE ACTIVITY; CENTRAL-NERVOUS-SYSTEM; FURIN-INDUCED CLEAVAGE; CLASS-I PRESENTATION;

D O I：

10.1016/j.toxicon.2012.07.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain strains of Escherichia coli. There is currently no available treatment for disease caused by these toxin-producing bacteria, and understanding the biology of the Shiga toxins might be instrumental in addressing this issue. In target cells, the toxins efficiently inhibit protein synthesis by inactivating ribosomes, and they may induce signaling leading to apoptosis. To reach their cytoplasmic target, Shiga toxins are endocytosed and transported by a retrograde pathway to the endoplasmic reticulum, before the enzymatically active moiety is translocated to the cytosol. The toxins thereby serve as powerful tools to investigate mechanisms of intracellular transport. Although Shiga toxins are a serious threat to human health, the toxins may be exploited for medical purposes such as cancer therapy or imaging. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1085 / 1107

页数：23

共 331 条

[1] Immunity profiles of wild-type and recombinant Shiga-Like toxin-encoding bacteriophages and characterization of novel double lysogens [J].