Viral suppression of RNA silencing

被引：29

作者：

Jiang Lin ^{[1
]}

Wei ChunHong ^{[1
]}

Li Yi ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2012年 / 55卷 / 02期

基金：

中国国家自然科学基金;

关键词：

RNA silencing; viral suppressor of RNA silencing; mechanisms; SMALL INTERFERING RNAS; DICER-LIKE PROTEINS; POTATO-VIRUS-X; ARGONAUTE PROTEINS; ANTIVIRAL DEFENSE; ARABIDOPSIS; MOVEMENT; POLYMERASES; DEGRADATION; PREVENTS;

D O I：

10.1007/s11427-012-4279-x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gene silencing (RNA silencing) plays a fundamental role in antiviral defense in plants, fungi and invertebrates. Viruses encode proteins that suppress gene silencing to counter host defense. Viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera and some viruses of insects and mammals. Recent studies have revealed that VSRs counter host defense and interfere with host gene regulation by interacting with RNA or important components of the RNA silencing pathway. Here, we review the current understanding of the complex mechanisms of VSRs that have been revealed by recent studies.

引用

页码：109 / 118

页数：10

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