Differential Adaptive Responses of Staphylococcus aureus to In Vitro Selection with Different Antimicrobial Peptides

被引：29
作者：
Shireen, Tahsina [1 ]
Singh, Madhuri [1 ]
Das, Tiyasa [1 ]
Mukhopadhyay, Kasturi [1 ]
机构：
[1] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 10期
关键词：
CELL-MEMBRANE; DAPTOMYCIN RESISTANCE; SURFACE-CHARGE; SUSCEPTIBILITY; MECHANISMS; STRATEGIES; DEFENSINS; ASYMMETRY; EVOLUTION; BACTERIA;
D O I：
10.1128/AAC.00780-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.
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收藏
页码：5134 / 5137
页数：4
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