EFFECT OF UNDIFFERENTIATED VERSUS HEPATOGENIC PARTIALLY DIFFERENTIATED MESENCHYMAL STEM CELLS ON HEPATIC AND COGNITIVE FUNCTIONS IN LIVER CIRRHOSIS

被引：12

作者：

Elberry, Dalia Azmy ^{[1
]}

Amin, Shaimaa Nasr ^{[1
]}

Esmail, Reham Shehab El Nemr ^{[2
]}

Rashed, Laila Ahmed ^{[3
]}

Gamal, Maha Mohamed ^{[1
]}

机构：

[1] Cairo Univ, Kasr Al Ainy Fac Med, Dept Med Physiol, Giza, Egypt

[2] Fayoum Univ, Dept Pathol, Fac Med, Al Fayyum, Egypt

[3] Cairo Univ, Kasr Al Ainy Fac Med, Dept Biochem, Giza, Egypt

来源：

EXCLI JOURNAL | 2016年 / 15卷

关键词：

liver; hepatic encephalopathy; stem cells; hippocampus; basal ganglia; ALCOHOLIC CIRRHOSIS; SYNAPTIC PROTEINS; STELLATE CELLS; BASAL GANGLIA; THIOACETAMIDE; ENCEPHALOPATHY; FIBROSIS; THROMBOSPONDIN-1; TRANSPLANTATION; PATHOGENESIS;

D O I：

10.17179/excli2016-645

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versus in vitro partially differentiated mesenchymal stem cells on liver cirrhosis and hepatic encephalopathy. 50 adult male albino rats constituted the animal model and were divided into the following groups: control, thioacetamide, undifferentiated mesenchymal stem cells and hepatocyte growth factor-differentiated mesenchymal stem cells groups. Cognitive assessment was achieved by open field test and Y-maze task. We measured serum alanine aminotransferase, albumin and transforming growth factor-beta1, gene expression of alpha-smooth muscle actin, matrix metalloprotein-2, its tissue inhibitor and apoptotic markers: Bax and Bcl2, brain glial fibrillary acidic protein, synaptophysin, and dopaminergic receptors.

引用

页码：652 / 670

页数：19

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