Takotsubo Cardiomyopathy The Pathophysiology

被引：26

作者：

Tranter, Matthew H. ^{[1
]}

Wright, Peter T. ^{[1
]}

Sikkel, Markus B. ^{[1
]}

Lyon, Alexander R. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Myocardial Funct Sect, London W12 0NN, England

[2] Royal Brompton Hosp, Cardiovasc Biomed Res Unit, London SW3 6LY, England

来源：

HEART FAILURE CLINICS | 2013年 / 9卷 / 02期

基金：

英国惠康基金;

关键词：

Tako tsubo; Apical balloning; Stress; Epinephrine; Stimulus trafficking; Beta-2 adrenergic receptor; APICAL BALLOONING SYNDROME; TAKO-TSUBO SYNDROME; LEFT-VENTRICULAR DYSFUNCTION; ST-SEGMENT ELEVATION; CLINICAL-FEATURES; STRESS CARDIOMYOPATHY; ANIMAL-MODEL; G-PROTEIN; PREVALENCE; BETA(2)-ADRENOCEPTOR;

D O I：

10.1016/j.hfc.2012.12.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Takotsubo Cardiomyopathy: The Pathophysiology Matthew H. Tranter, Peter T. Wright, Markus B. Sikkel, and Alexander R. Lyon Takotsubo cardiomyopathy (TTC) is an acute heart failure syndrome classically characterized by hypocontractile apical and midventricular regions of the left ventricle, with a compensatory hypercontractile base. Available data support the hypothesis that TTC and atypical TTC-like disorders are primarily induced by catecholaminergic overstimulation, with epinephrine playing a crucial role. Knowledge from the available preclinical models should be used to guide the development of potential clinical trials in the most severe cases, where rates of acute morbidity and mortality are highest, and also to prevent recurrence in susceptible individuals.

引用

页码：187 / +

页数：12

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