Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus

被引：79
作者：
de SF-Tischer, PC
Talarico, LB
Noseda, MD
Guimaraes, SMPB
Damonte, EB
Duarte, MER
机构：
[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-81531990 Curitiba, Parana, Brazil
[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Virol Lab, RA-1428 Buenos Aires, DF, Argentina
[3] Inst Bot, Secretaria Meio Ambiente Estado Sao Paulo, Secao Ficol, BR-04301902 Sao Paulo, Brazil
来源：
CARBOHYDRATE POLYMERS | 2006年 / 63卷 / 04期
关键词：
iota/kappa-carrageenan; chemical structure; antiviral activity; herpes simplex virus; dengue virus; Meristiella gelidium; solieriaceae;
D O I：
10.1016/j.carbpol.2005.09.020
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaccae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6-956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：459 / 465
页数：7
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