Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis

被引：36

作者：

Pan, Xiongfeng ^{[1
]}

Wu, Xinyin ^{[1
]}

Kaminga, Atipatsa C. ^{[1
,2
]}

Wen, Shi Wu ^{[3
,4
]}

Liu, Aizhong ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China

[2] Mzuzu Univ, Dept Math & Stat, Mzuzu, Malawi

[3] Univ Ottawa, Dept Obstet & Gynaecol, Ottawa, ON, Canada

[4] Ottawa Hosp Res Inst, Ottawa, ON, Canada

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2019年 / 11卷

基金：

加拿大健康研究院;

关键词：

dehydroepiandrosterone; dehydroepiandrosterone sulfate; Alzheimer's disease; meta-analysis; systematic review; CRT PLASMA-LEVELS; DHEA-S; COGNITIVE FUNCTION; LOW TESTOSTERONE; SERUM-LEVELS; RAT MODEL; MEMORY; BRAIN; WOMEN; AGE;

D O I：

10.3389/fnagi.2019.00061

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background and Purpose: Previous studies found inconsistent results for the relationship between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate. This study performed a systematic review and meta-analysis to evaluate previous studies' results on this relationship. Method: Studies related to this outcome were obtained using a systematic search from the electronic databases of PubMed, Embase, Web of Science, and Psyc-ARTICLES in March 2018. The random-effects model was used to measure the strength of the association between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate, using the standardized mean difference. Results: Thirty-one eligible studies were included in the final analysis. There was no statistically significant association between the level of dehydroepiandrosterone and Alzheimer's disease (standardized mean difference: 0.51, 95% confidence interval: -0.44 to 1.45, Z = 1.06, p = 0.29). On the other hand, lower level dehydroepiandrosterone sulfate was observed in patients with Alzheimer's disease than in controls (standardized mean difference: -0.69, 95% confidence interval: -1.17 to -0.22, Z = -2.84, p < 0.01). Conclusion: Decreased dehydroepiandrosterone sulfate concentrations may be an important indicator for Alzheimer's disease, although whether dehydroepiandrosterone sulfate could be used as a diagnostic tool requires further research.

引用

页数：12

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