Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population

被引：9

作者：

Charoute, Hicham ^{[1
]}

Kefi, Rym ^{[2
]}

Bounaceur, Safaa ^{[1
]}

Benrahma, Houda ^{[1
]}

Reguig, Ahmed ^{[1
]}

Kandil, Mostafa ^{[3
]}

Rouba, Hassan ^{[1
]}

Bakhchane, Amina ^{[1
]}

Abdelhak, Sonia ^{[2
]}

Barakat, Abdelhamid ^{[1
]}

机构：

[1] Inst Pasteur, Human Mol Genet Lab, Casablanca 20360, Morocco

[2] Univ Tunis El Manar, Inst Pasteur Tunis, Biomed Genom & Oncogenet Lab LR 11 IPT 05, Tunis, Tunisia

[3] Univ Chouaib Doukkali, Fac Sci, Equipe Anthropogenet & Biotechnol, El Jadida, Morocco

来源：

MITOCHONDRIAL DNA PART A | 2018年 / 29卷 / 01期

关键词：

Mitochondria; hypervariable segment 1; mitochondrial variant; genetic association; Type; 2; diabetes; PREVALENCE; SUSCEPTIBILITY; POLYMORPHISMS; DYSFUNCTION; ADULTS;

D O I：

10.1080/24701394.2016.1233530

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher's exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (p =.02) and C16320T (p =.03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.

引用

页码：9 / 13

页数：5

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