Extra-Esophageal Presentation of Gastroesophageal Reflux Disease: 2020 Update

被引：71

作者：

Durazzo, Marilena ^{[1
,2
]}

Lupi, Giulia ^{[1
,2
]}

Cicerchia, Francesca ^{[1
,2
]}

Ferro, Arianna ^{[1
,2
]}

Barutta, Federica ^{[1
,2
]}

Beccuti, Guglielmo ^{[1
,2
]}

Gruden, Gabriella ^{[1
,2
]}

Pellicano, Rinaldo ^{[3
]}

机构：

[1] Univ Turin, Dept Med Sci, Cso AM Dogliotti 14, I-10126 Turin, Italy

[2] Citta Salute & Sci Hosp, Internal Med Unit 3, Cso Bramante 88, I-10126 Turin, Italy

[3] Citta Salute & Sci Hosp, Unit Gastroenterol, Cso Bramante 88, I-10126 Turin, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期

关键词：

gastroesophageal reflux; cough; asthma; laryngo-pharyngeal reflux; chest pain; tooth erosions; NONCARDIAC CHEST-PAIN; HIGH-RESOLUTION MANOMETRY; PUMP INHIBITOR THERAPY; HIGH-DOSE RABEPRAZOLE; CHRONIC COUGH; DOUBLE-BLIND; LARYNGOPHARYNGEAL REFLUX; SALIVARY PEPSIN; ASTHMA; ACID;

D O I：

10.3390/jcm9082559

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gastroesophageal reflux disease (GERD) is defined by the presence of symptoms induced by the reflux of the stomach contents into the esophagus. Although clinical manifestations of GERD typically involve the esophagus, extra-esophageal manifestations are widespread and less known. In this review, we discuss extra-esophageal manifestations of GERD, focusing on clinical presentations, diagnosis, and treatment. Common extra-esophageal manifestations of GERD include chronic cough, asthma, laryngitis, dental erosions, and gingivitis. Extra-esophageal involvement can be present also when classic GERD symptoms are absent, making the diagnosis more challenging. Although available clinical studies are heterogeneous and frequently of low quality, a trial with proton pump inhibitors can be suggested as a first-line diagnostic strategy in case of suspected extra-esophageal manifestations of GERD.

引用

页码：1 / 21

页数：21

共 94 条

[1] Approach to the patient with presumed extraoesophageal GERD [J].