The Effect of PAI-1 4G/5G Polymorphism and Clinical Factors on Coronary Artery Occlusion in Myocardial Infarction

被引：13
作者：
Parpugga, Tajinder Kumar [1 ]
Tatarunas, Vacis [1 ]
Skipskis, Vilius [1 ]
Kupstyte, Nora [1 ,2 ]
Zaliaduonyte-Peksiene, Diana [2 ]
Lesauskaite, Vaiva [1 ]
机构：
[1] Lithuanian Univ Hlth Sci, Inst Cardiol, LT-50009 Kaunas, Lithuania
[2] Lithuanian Univ Hlth Sci, Dept Cardiol, LT-50009 Kaunas, Lithuania
来源：
DISEASE MARKERS | 2015年 / 2015卷
关键词：
PLASMINOGEN-ACTIVATOR INHIBITOR-1; GENETIC RISK-FACTORS; PLASMA PAI-1; PROMOTER; INFLAMMATION; ASSOCIATION; EXPRESSION; GENOTYPE; (PAI)-1; TYPE-1;
D O I：
10.1155/2015/260101
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective. Data on the impact of PAI-1-675 4G/5G genotype for fibrinolysis during myocardial infarction are inconsistent. The aim of our study was to evaluate the association of clinical and genetic (PAI-1-675 4G/5G polymorphism) factors with coronary artery occlusion in patients with myocardial infarction. Materials and Methods. PAI-1-675 4G/5G detection was achieved by using Sanger sequencing in a sample of patients hospitalized for stent implantation due to myocardial infarction. We categorized the patients into two groups: patients with coronary artery occlusion and patients without coronary artery occlusion according to angiographic evaluation. Results. We identified n = 122 (32.4%) 4G/4G, n = 186 (49.5%) 4G/5G, and n = 68 (18.1%) 5G/5G PAI-1 genotype carriers. Univariate and multivariate analysis showed that only the 4G/5G genotype was associated with coronary artery occlusion (OR: 1.656 and 95% CI: 1.009-2.718, n = 0.046). Conclusions. Our results showed that carriers of PAI-1 4G/5G genotype with myocardial infarction have increased odds of coronary artery occlusion more than 1.6 times in comparison to the carriers of homozygous genotypes.
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页数：8
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