Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis

被引：34

作者：

Xu, Hui ^{[1
]}

Huang, Wei ^{[1
]}

He, Qing-Li ^{[1
]}

Zhao, Zhi-Xiong ^{[1
]}

Zhang, Feng ^{[1
]}

Wang, Renxiao ^{[1
]}

Kang, Jingwu ^{[2
]}

Tang, Gong-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Beijing 100864, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Analyt Chem Lab, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 42期

基金：

中国国家自然科学基金;

关键词：

antibiotics; base excision repair; DNA damage; yatakemycin; YtkR2; DAMAGED DNA; I-TASSER; ALKYLATION; CHEMISTRY; INCLUDES;

D O I：

10.1002/anie.201204109

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：10532 / 10536

页数：5

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