Control of innate and adaptive immunity by the inflammasome

被引：72

作者：

Ciraci, Ceren ^{[1
]}

Janczy, John R. ^{[1
,2
]}

Sutterwala, Fayyaz S. ^{[1
,2
,3
,4
]}

Cassel, Suzanne L. ^{[1
,3
]}

机构：

[1] Univ Iowa, Carver Coll Med, Inflammat Program, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Grad Program Immunol, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[4] Vet Affairs Med Ctr, Iowa City, IA 52241 USA

来源：

MICROBES AND INFECTION | 2012年 / 14卷 / 14期

关键词：

Inflammasome; Innate immunity; Adaptive immunity; NLRP3; INFLAMMASOME; NALP3; CUTTING EDGE; URIC-ACID; PATTERN-RECOGNITION; OXIDATIVE STRESS; CRUCIAL ROLE; ACTIVATION; PROTEIN; IL-1-BETA;

D O I：

10.1016/j.micinf.2012.07.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1263 / 1270

页数：8

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