Study of potential biomedical application of sol-gel derived Zn-doped SiO2 hydroxypropyl cellulose nanohybrids

被引：6
作者：
Angelova, Tsvetelina [1 ]
Rangelova, Nadezhda [2 ]
Georgieva, Nelly [1 ]
Nemska, Veronica [1 ]
Stoyanova, Tihomira [3 ]
Uzunova, Veselina [3 ]
Aleksandrov, Lyubomir [4 ]
Tzoneva, Rumiana [3 ]
机构：
[1] Univ Chem Technol & Met, Dept Biotechnol, 8 St Kliment Ohridski Blvd, BU-1756 Sofia, Bulgaria
[2] Univ Chem Technol & Met, Dept Fundamentals Chem Technol, 8 St Kliment Ohridski Blvd, BU-1756 Sofia, Bulgaria
[3] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 21, BU-1113 Sofia, Bulgaria
[4] Bulgarian Acad Sci, Inst Gen & Inorgan Chem, Acad G Bonchev Str,Bl 11, BU-1113 Sofia, Bulgaria
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 100卷
关键词：
Sol-gel method; Silica hybrid materials; Antibacterial properties; Biomedical application; HYBRID MATERIALS; ANTIBACTERIAL ACTIVITY; IN-VITRO; ZINC; SILVER; NANOPARTICLES; CYTOTOXICITY; TOXICITY; BACTERIA; IMPACT;
D O I：
10.1016/j.msec.2019.03.018
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A series of Zn-doped hybrid materials based on silica from tetraethoxysilane (TEOS) and hydroxypropyl cellulose (HPC) were prepared by a sol-gel route. The structure, morphology and thermal behavior of synthesized hybrids were characterized by infrared (IR) spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), transmission electron microscopy (TEM) and differential thermal analysis with thermogravimetric analysis (DTA/TG). The obtained materials were investigated for a potential biomedical application. The antibacterial properties of hybrids were investigated by measuring the inhibition zones formed around the materials containing different zinc content in presence of reference strains of Gram-positive and Gram-negative bacteria. The biocompatibility tests showed no cytotoxicity and genotoxicity, as well as no changes in actin cytoskeleton organization for hybrids with Zn content below 5 wt%.
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收藏
页码：608 / 615
页数：8
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