Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population -: The MONICA/KORA cohort study

被引:149
作者
Meisinger, Christa [2 ,3 ]
Koenig, Wolfgang [1 ]
Baumert, Jens [3 ]
Doering, Angela [3 ]
机构
[1] Univ Ulm Med Ctr, Dept Internal Med 2, D-89081 Ulm, Germany
[2] MONICA KORA Myocardial Infarct Registry, Cent Hosp Augsburg, Augsburg, Germany
[3] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany
关键词
men; mortality; risk factors; serum uric acid; C-reactive protein;
D O I
10.1161/ATVBAHA.107.160184
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation. Methods and Results-The study was based on 3604 men (45 to 74 years of age) who participated in 1 of the 3 MONICA Augsburg surveys between 1984 and 1995. All participants were prospectively followed within the framework of the Cooperative Health Research in the Region of Augsburg (KORA). Up to December 31, 2002, there occurred 809 total deaths, 359 CVD deaths, and 297 incident MIs. In a Cox model, comparing extreme quartiles of the UA distribution, the hazard ratio for CVD mortality was 1.44 (95% confidence interval [CI] 1.04 to 2.0), and for all-cause mortality it was 1.40 (95% CI 1.13 to 1.74) after adjustment for conventional cardiovascular risk factors, CRP, and diuretic intake. However, UA was not associated with incident MI after multivariable adjustment. Conclusions-High UA levels were independently associated with CVD mortality as well as all-cause mortality but not with incident MI in middle-aged men from the general population.
引用
收藏
页码:1186 / 1192
页数:7
相关论文
共 34 条
  • [1] Uric acid and cardiovascular risk
    Alderman, MH
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (02) : 126 - 130
  • [2] TOWARDS THE PHYSIOLOGICAL-FUNCTION OF URIC-ACID
    BECKER, BF
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (06) : 615 - 631
  • [3] ROLE OF URIC-ACID AS AN ENDOGENOUS RADICAL SCAVENGER AND ANTIOXIDANT
    BECKER, BF
    REINHOLZ, N
    LEIPERT, B
    RASCHKE, P
    PERMANETTER, B
    GERLACH, E
    [J]. CHEST, 1991, 100 (03) : S176 - S181
  • [4] Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study
    Culleton, BF
    Larson, MG
    Kannel, WB
    Levy, D
    [J]. ANNALS OF INTERNAL MEDICINE, 1999, 131 (01) : 7 - +
  • [5] MYOCARDIAL MALONDIALDEHYDE AND URIC-ACID RELEASE AFTER SHORT-LASTING CORONARY OCCLUSIONS DURING CORONARY ANGIOPLASTY - POTENTIAL MECHANISMS FOR FREE-RADICAL GENERATION
    DESCHEERDER, IK
    VANDEKRAAY, AMM
    LAMERS, JMJ
    KOSTER, JF
    DEJONG, JW
    SERRUYS, PW
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1991, 68 (04) : 392 - 395
  • [6] ATHEROSCLEROSIS AND URATE METABOLISM
    EMMERSON, BT
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1979, 9 (04): : 451 - 454
  • [7] Sevum uric acid and cardiovascular mortality - The NHANES I epidemiologic follow-up study, 1971-1992
    Fang, J
    Alderman, MH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18): : 2404 - 2410
  • [8] Uric acid and the immune response
    Gersch, Michael S.
    Johnson, Richard J.
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (11) : 3046 - 3047
  • [9] Gotoh Minehiro, 2005, Endocr Regul, V39, P119
  • [10] Mechanisms of disease - Inflammation, atherosclerosis, and coronary artery disease
    Hansson, GK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (16) : 1685 - 1695